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m-Chlorophenylbiguanide hydrochloride
CAS No. 2113-05-5
m-Chlorophenylbiguanide hydrochloride ( 1-(3-Chlorophenyl)biguanidehydrochloride )
产品货号. M27652 CAS No. 2113-05-5
m-Chloro苯基双胍盐酸盐是一种 5-HT3 受体激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | ￥340 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称m-Chlorophenylbiguanide hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述m-Chloro苯基双胍盐酸盐是一种 5-HT3 受体激动剂。
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产品描述m-Chlorophenylbiguanide hydrochloride is a 5-HT3 receptor agonist. m-Chlorophenylbiguanide hydrochloride selectively binds 5-HT3(Ki: 0.002 μM) over 5-HT1A(Ki: 10 μM) and 5-HT2(Ki: 10 μM) receptors but also binds to high and low affinity sites on the dopamine transporter(DAT; IC50s: 0.4 and 34.8 μM, respectively, in rat caudate putamen synaptosomal membranes).(In Vivo):m-Chlorophenylbiguanide hydrochloride induces depolarization of isolated rat vagus nerve and stimulates inositol phosphate formation in rat frontocingulate cortical slices (EC50s = 0.05 and 4.2 μM, respectively).m-Chlorophenylbiguanide hydrochloride induces bradycardia, an effect that can be reversed by the 5-HT3 receptor antagonist ondansetron, in anaesthetized cats (ED50 = 20.3 nmol/kg).
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体外实验——
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体内实验Animal Model:Wistar male ratsDosage:80, 160 and 320 nM Administration:Ventricle injection Result:Decreased water intake induced by water deprivation, acute salt load and hypovolemia.
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同义词1-(3-Chlorophenyl)biguanidehydrochloride
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number2113-05-5
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分子量248.11
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分子式C8H11Cl2N5
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纯度>98% (HPLC)
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溶解度In Vitro:?H2O : 125 mg/mL (503.81 mM)
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SMILESCl.NC(=N)NC(=N)Nc1cccc(Cl)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Tsuji H, Eto T, Sakamoto Y. Synthesis and Hydrolytic Degradation of Substituted Poly(DL-Lactic Acid)s. Materials (Basel). 2011 Aug 10;4(8):1384-1398.
